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GUARANá
Parts used and where grown: Guaraná is an evergreen vine indigenous to the Amazon basin. The vast majority of guaraná is grown in a small area in northern Brazil. Guaraná gum or paste is derived from the seeds and is used in herbal preparations.
Guaraná has been used in connection with the following conditions (refer to the individual health concern for complete information):
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 Reliable
and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies
suggesting a health benefit or minimal health benefit. An herb is primarily supported by traditional use, or
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Historical or traditional use (may or may not be supported by scientific studies): The indigenous people of the Amazon rain forest have used crushed guaraná seed as a beverage and a medicine. Guaraná was used to treat diarrhea, decrease fatigue, reduce hunger, and to help arthritis.1 It also has a history of use in treating hangovers from alcohol abuse and headaches related to menstruation.
Active constituents: Caffeine and the closely related alkaloids theobromine and theophylline make up the primary active constituents in guaraná. Caffeine’s effects are well known and include stimulating the central nervous system, increasing metabolic rate, and having a mild diuretic effect.2 One preliminary trial found no significant actions on thinking or mental function in humans taking guaraná.3 Guaraná also contains tannins, which act as astringents and may prevent diarrhea. However, this action has not been studied in human clinical trials.
How much is usually taken? A cup of guaraná, prepared by adding 1/4–1/2 teaspoon (1–2 grams) of crushed seed or resin to 1 cup (250 ml) of water and boiling for ten minutes, can be consumed three times per day.4 Each cup may provide up to 50 mg of caffeine.
Are there any side effects or interactions? As with any caffeinated product, guaraná may cause insomnia, trembling, anxiety, palpitations, and urinary frequency.5 Guaraná should be avoided during pregnancy and breast-feeding.
Are there any drug interactions? Certain medications may interact with guaraná. Refer to the drug interactions safety check for a list of those medications.
References:
1. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 349.
2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 293–4.
3. Galduroz JC, Carlini EA. The effects of long-term administration of guarana on the cognition of normal, elderly volunteers. Rev Paul Med 1996;114:1073–8.
4. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 349.
5. Gruenwald J, Brendler T, Jaenicke C, et al. (eds). PDR for Herbal Medicines. Montvale, NJ: Medical Economics, 1998, 1017–8.
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