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ZAFIRLUKAST
Safetychecker
Summary
(for details about the summarized interactions, read the full article)
Avoid: Reduced drug absorption/bioavailability—Avoid these supplements
when taking this medication since the supplement may decrease the absorption and/or activity
of the medication in the body. |
Food |
|
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
Willow* |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
Interactions with Herbs
Willow
(Salix alba)
Willow bark contains salicin, a substance similar to aspirin. Research has shown that aspirin significantly
increases blood levels of zafirlukast,1 which would increase the likelihood of side
effects from zafirlukast. The same thing could theoretically happen if people took willow bark
along with zafirlukast, although no studies have investigated this specific interaction.
People may want to avoid combining willow bark with zafirlukast due to the possibility of
increased side effects.
Interactions with Foods and Other Compounds
Food
The ingestion of food along with zafirlukast can reduce the overall absorption of the drug by
about 40%.2 Therefore, zafirlukast should be taken one hour before or two hours
after a meal.
References:
1. Kelloway JS. Zafirlukast: the first leukotriene-receptor antagonist approved for the treatment of asthma. Ann Pharmacother 1997;31(9):1012–21.
2. Kelloway JS. Zafirlukast: the first leukotriene-receptor antagonist approved for the treatment of asthma. Ann Pharmacother 1997;31(9):1012–21.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
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Learn more about the authors of Safetychecker.
The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.
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