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PROCHLORPERAZINE
Safetychecker Summary
for Prochlorperazine
(for details about the summarized interactions, read the full article)
Avoid: Reduced drug absorption/bioavailability—Avoid these supplements
when taking this medication since the supplement may decrease the absorption and/or activity
of the medication in the body. |
Antacids |
|
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
Alcohol Lithium (prescription) Lithium (supplements) |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
Interactions with Dietary Supplements
Lithium
Lithium is a mineral that may be present in some supplements and is also used in large amounts
to treat mood disorders, such as bipolar disorder. Taking lithium at the same time as
phenothiazines may result in drug side effects such as disorientation and
unconsciousness.1 Though no studies have investigated whether the small amount of
lithium available in supplements might interact with prochlorperazine to cause similar
effects, people taking the drug should exercise caution when supplementing with lithium.
Interactions with Foods and Other Compounds
Alcohol
Taking prochlorperazine may increase or prolong the effects of alcohol, such as drowsiness,
dizziness, and poor coordination.2 Therefore, people taking prochlorperazine should
avoid drinking alcohol, especially when they must stay alert.
Antacids
Many antacid products contain aluminum
hydroxide, which reduces the absorption of phenothiazine drugs.3 Though no
studies are available that confirm an interaction between prochloroperazine and antacids,
people who are using antacids should take them an hour before or two hours after the drug.
References:
1. Burnham TH, ed. Central Nervous System Agents, Antipsychotic Agents. In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 2001, 945–65.
2. Sifton DW, et. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2986–8.
3. Burnham TH, ed. Central Nervous System Agents, Antipsychotic Agents. In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 2001, 945–65.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Learn more about Healthnotes, the company.
Learn more about the authors of Safetychecker.
The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.
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