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PENTOXIFYLLINE

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Pentoxifylline decreases blood thickness and improves red blood cell flexibility. Pentoxifylline is used to improve symptoms of intermittent claudication and in the treatment of other circulatory disorders.

Safetychecker Summary for Pentoxifylline
(for details about the summarized interactions, read the full article)

Beneficial May be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better.

Vitamin E

Depletion or interference

None known

Side effect reduction/prevention

None known

Reduced drug absorption/bioavailability

None known

Adverse interaction

None known

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Interactions with Dietary Supplements

Vitamin E
The combination of vitamin E and pentoxifylline has been used successfully to reduce damage to normal tissues caused by radiation therapy.1

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Interactions with Foods and Other Compounds

Food
Pentoxifylline should be taken with meals.2

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References: Top

1. Delanian S, Balla-Mekias S, Lefaix JL. Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. J Clin Oncol 1999;17:3283–90.

2. Threlkeld DS, ed. Blood Modifiers, Hemorheologic Agent, Pentoxifylline. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1997, 89f–9g.