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NIFEDIPINE
Safetychecker Summary
for Nifedipine
(for details about the summarized interactions, read the full article)
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
Pleurisy root* Tobacco* |
Check: Other—Before taking any of these supplements or eating any of
these foods with your medication, read this article in full for details. |
Grapefruit juice |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Reduced drug absorption/bioavailability |
None known |
Interactions with Herbs
Pleurisy
root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides,
it is best to avoid use of pleurisy root with heart medications such as calcium channel
blockers.1
Interactions with Foods and Other Compounds
Grapefruit juice
Ingestion of grapefruit juice has been shown to increase the absorption of felodipine (a drug similar in structure and action to
that of nifedipine) and to increase the adverse effects of the medication in patients with hypertension. People taking nifedipine or similar
drugs should not consume grapefruit juice or grapefruit, unless they have discussed it with
their physician.2
Food
Nifedipine may be taken with or without food.3 Nifedipine products should be
swallowed whole, without crushing or chewing.4
Tobacco
In a double-blind study of ten cigarette smokers with angina treated with nifedipine for one week, angina
episodes were significantly reduced during the nonsmoking phase compared to the smoking
phase.5 People with angina taking nifedipine should not smoke tobacco.
References:
1. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.
2. Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefuit Juice-Drug Interactions. Br J Clin Pharmacol 1998;46:101–110.
3. Reitberg DP, Love SJ, Quercia GT, Zinny MA. Effect of food on nifedipine pharmacokinetics. Clin Pharmacol Ther 1987;42:72–5.
4. Threlkeld DS, ed. Diuretics and Cardiovasculars, Calcium Channel Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1996, 149m–9n.
5. Deanfield J, Wright C, Krikler S, et al. Cigarette smoking and the treatment of angina with propranolol, atenolol, and nifedipine. N Engl J Med 1984;310:951–4.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Learn more about Healthnotes, the company.
Learn more about the authors of Safetychecker.
The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.
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