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NEFAZODONE
Nefazodone is a drug used to treat people with depression.
Safetychecker Summary
for Nefazodone
(for details about the summarized interactions, read the full article)
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
St. John’s wort* |
Check: Other—Before taking any of these supplements or eating any of
these foods with your medication, read this article in full for details. |
Digitalis |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Reduced drug absorption/bioavailability |
None known |
Interactions with Herbs
Digitalis (Digitalis lanata, Digitalis
purpurea)
Digitalis refers to a family of plants commonly called foxglove that contain digitalis
glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin.
Nefazodone increased serum digoxin levels in a three-way crossover study of 18 healthy men.1 No interactions between nefazodone and digitalis have been reported. Until more is known, nefazodone and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use.
St. John’s
wort (Hypericum perforatum)
Although there have been no interactions reported in the medical literature, it is best to
avoid using nefazodone with St. John’s wort unless you are under the supervision of a
qualified healthcare professional.
Interactions with Foods and Other Compounds
Food
Nefazodone may be taken with or without food.2
Alcohol
People taking nefazodone are advised to avoid alcohol.3
References:
1. Dockens RC, Greene DS, Barbhaiya RH. Assessment of pharmacokinetic and pharmacodynamic drug interactions between nefazodone and digoxin in healthy male volunteers. J Clin Pharmacol 1996;36:160–7.
2. Dockens RC, Greene DS, Barbhaiya RH. The lack effect of food on the bioavailability of nefazodone tablets. Biopharm Drug Dispos 1996;17:135–43.
3. Threlkeld DS, ed. Central Nervous System Drugs, Antidepressants, Trazodone. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1995, 263i–3k.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Learn more about Healthnotes, the company.
Learn more about the authors of Safetychecker.
The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.
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