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LABETALOL
Labetalol is used to treat high blood pressure.
Safetychecker Summary
for Labetalol
(for details about the summarized interactions, read the full article)
 May be Beneficial: Supportive
interaction—Taking these supplements may support or otherwise help your medication
work better. |
Food |
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
Potassium High-potassium foods* Pleurisy root* |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Reduced drug absorption/bioavailability |
None known |
Interaction with Dietary Supplements
Potassium
Three kidney transplant patients developed hyperkalemia (high blood potassium levels), a
potentially dangerous condition, following intravenous administration of
labetalol.1 Additional research is needed to determine whether taking oral
labetalol together with potassium supplements might also lead to elevated blood levels of
potassium. However, some other beta-blockers (called “nonselective” beta-blockers)
are known to decrease the uptake of potassium from the blood into the cells,2
leading to hyperkalemia.3 People taking beta-blockers should therefore avoid taking
potassium supplements, or eating large quantities of fruit (e.g., bananas), unless directed to do so by their
doctor.
Interactions with Herbs
Pleurisy
root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides,
it is best to avoid use of pleurisy root with heart medications such as
beta-blockers.4
Interaction with Food and Other Compounds
Food
Taking labetalol with food greatly increases the absorption of the drug.5
Therefore, labetalol should be taken with a meal.
References:
1. Arthur S, Greenberg A. Hyperkalemia associated with intravenous labetalol therapy for acute hypertension in renal transplant recipients. Clin Nephrol 1990;33:269–71.
2. Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med 1980;302:431–4.
3. Lundborg P. The effect of adrenergic blockade on potassium concentrations in different conditions. Acta Med Scand Suppl 1983;672:121–6 [review].
4. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.
5. Daneshmend TK, Roberts CJ. the influence of food on the oral and intravenous pharmacokinetics of a high clearance drug: a study with labetalol. Br J Clin Pharmacol 1982;14:73–8.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Learn more about Healthnotes, the company.
Learn more about the authors of Safetychecker.
The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.
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