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KETOROLAC
Ketorolac is used orally to treat moderately severe acute pain (e.g., migraine headaches), but should not be used for more than five days. It is also used in the eye to treat itching due to seasonal allergies and to prevent inflammation following cataract surgery.
Safetychecker Summary
for Ketorolac
(for details about the summarized interactions, read the full article)
Avoid: Reduced drug absorption/bioavailability—Avoid these supplements
when taking this medication since the supplement may decrease the absorption and/or activity
of the medication in the body. |
High-fat meal |
|
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
Lithium* Potassium White willow* |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
Interactions with Dietary Supplements
Lithium
Lithium is a mineral that may be present in some supplements and is also used in large amounts
to treat mood disorders such as manic-depression (bipolar disorder). Most NSAIDs inhibit the excretion
of lithium from the body, resulting in higher blood levels of the mineral, though sulindac may have an opposite effect.1
Since major changes in lithium blood levels can produce unwanted side effects or interfere
with its efficacy, NSAIDs should be used with caution, and only under medical supervision, in
people taking lithium supplements.
Potassium
A 50-year-old male developed high blood levels of potassium following eight days of ketorolac
treatment.2 Additional research is needed to determine whether taking ketorolac
together with supplemental potassium might enhance this side effect. individuals taking oral
ketorolac should probably avoid potassium supplements and salt substitutes until more
information is available.
Interactions with Herbs
White willow bark
(Salix alba)
White willow bark contains salicin, which is related to aspirin. Both salicin and aspirin produce
anti-inflammatory effects after they have been converted to salicylic acid in the body. The
administration of salicylates like aspirin to individuals taking oral NSAIDs may result in
reduced blood levels of NSAIDs.3 Though no studies have investigated interactions
between white willow bark and NSAIDs, people taking NSAIDs should avoid the herb until more
information is available.
Interactions with Foods and Other Compounds
Food
Taking ketorolac with a high-fat breakfast slows the speed of drug absorption by about an
hour, but it does not affect overall blood levels of the drug.4 To lessen stomach
upset, ketorolac tablets should be taken with a meal or a snack.
References:
1. Olin BR, ed. Central Nervous System Drugs, Analgesics and Anti-inflammatory Drugs, Nonsteroidal Anti-inflammatory Agents, In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 1993, 1172–90.
2. Kelley M, Bastani B. Ketorolac-induced acute renal failure and hyperkalemia. Clin Nephrol 1995;44:276–7 [letter].
3. Olin BR, ed. Central Nervous System Drugs, Analgesics and Anti-inflammatory Drugs, Nonsteroidal Anti-inflammatory Agents, In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 1993, 1172–90.
4. Mroszczak EJ, Jung D, Yee J, et al. Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals. Pharmacotherapy 1990;10:33S–9S.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Learn more about Healthnotes, the company.
Learn more about the authors of Safetychecker.
The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.
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