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FENOFIBRATE
Fenofibrate is used to lower elevated cholesterol and triglyceride levels when diet, exercise, and weight loss programs are ineffective. It is in a family of medications known as cholesterol-lowering drugs.
Safetychecker Summary
for Fenofibrate
(for details about the summarized interactions, read the full article)
 May be Beneficial: Side effect
reduction/prevention—Taking these supplements may help reduce the likelihood and/or
severity of a potential side effect caused by the medication. |
Folic acid Vitamin B12 Vitamin B6 Vitamin C Vitamin E |
| May be Beneficial: Supportive
interaction—Taking these supplements may support or otherwise help your medication
work better. |
Food |
| Depletion or interference |
None known |
| Reduced drug absorption/bioavailability |
None known |
| Adverse interaction |
None known |
Interactions with Dietary Supplements
Vitamin C and Vitamin E
Several studies have shown that fenofibrate enhances the toxic effect of ultraviolet (UV)
radiation from the sun, which might result in side effects such as skin rashes. One controlled
study showed that taking 2 grams of vitamin C and 1,000 IU of vitamin E prior to ultraviolet
exposure dramatically blocked UV-fenofibrate damage to red blood cells.1 though
further controlled studies are needed, people taking fenofibrate should probably supplement
with vitamins C and E until more information is available.
Folic acid, Vitamin B6, and Vitamin B12
Increased blood levels of homocysteine are
associated with increased risk of
atherosclerosis and heart disease. One
study revealed that fenofibrate dramatically increases blood homocysteine levels, though blood
levels of vitamins were not reduced.2 Further research is needed to determine
whether supplemental folic acid, vitamin B6, and vitamin B12 might lower fenofibrate-induced
elevations in homocysteine blood levels.
Interactions with Foods and Other Compounds
Food
Taking fenofibrate together with food dramatically increases the absorption of the
drug.3 Therefore fenofibrate should be taken with a meal.
References:
1. Eberlein-Konig B, Placzek M, Przybilla B. Phototoxic lysis of erythrocytes from humans is reduced after oral intake of ascorbic acid and d-alpha-tocopherol. Photodermatol Photoimmunol Photomed 1997;13:173–7.
2. Dierkes J, Westphal S, Luley C. Serum homocysteine increases after therapy with fenofibrate or bezafibrate. Lancet 1999;354:219–20.
3. Sifton DW, et. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 476–8.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Learn more about Healthnotes, the company.
Learn more about the authors of Safetychecker.
The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.
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