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AMLODIPINE
Combination drug: Lotrel®
Safetychecker Summary
for Amlodipine
(for details about the summarized interactions, read the full article)
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
Pleurisy root* |
Check: Other—Before taking any of these supplements or eating any of
these foods with your medication, read this article in full for details. |
DHEA Grapefruit juice |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Reduced drug absorption/bioavailability |
None known |
Interactions with Dietary Supplements
Dehydroepiandrosterone (DHEA)
Amlodipine has been shown to raise blood levels of DHEA-sulfate in insulin-resistant, obese
men with high blood pressure.1
Interactions with Herbs
Pleurisy
root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides,
it is best to avoid use of pleurisy root with heart medications such as calcium channel
blockers.2
Interactions with Foods and Other Compounds
Grapefruit juice
Ingestion of grapefruit juice has been shown to increase the absorption of felodipine (a drug similar in structure and action to
that of amlodipine) and to increase the adverse effects of the medication in patients with
hypertension. Until more is known, it seems that grapefruit juice should not be ingested by
people taking amlodipine or similar drugs.3 The same effects might be seen from
eating grapefruit as from drinking its juice.
Food
Amlodipine may be taken with or without food.4
References:
1. Beer NA, Jakubowicz DJ, Beer RM, Nestler JE. The calcium channel blocker amlodipine raises serum dehydroepiandrosterone sulfate and androstenedione, but lowers serum cortisol, in insulin-resistant obese and hypertensive men. J Clin Endocrinol Metab 1993;76:1464–9.
2. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.
3. Bailey DG, Arnold MO, Strong HA, Munoz C, Spence JD, et al. Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. Clin Pharmacol Ther 1993;54:589–94.
4. Faulkner JK, Hayden ML, Chasseaud LF, Taylor T. Absorption of amlodipine unaffected by food. Solid dose equivalent to solution dose. Arzneimittelforschung 1989;39:799–801.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Learn more about Healthnotes, the company.
Learn more about the authors of Safetychecker.
The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.
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