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CLONIDINE
Combination drug: Combipres®
Clonidine is a drug that blocks signals in the brain controlling heart rate and blood pressure. It is used to lower blood pressure in people with hypertension. It is available alone in oral tablets, skin patches (Catapres®-TTS), and in a form for intravenous (iv) injection; and in an oral combination product. Clonidine is used with narcotics to treat severe pain and as an adjunct to alcohol withdrawal, narcotic detoxification, and quitting smoking.
Safetychecker Summary
for Clonidine
(for details about the summarized interactions, read the full article)
 May be Beneficial: Supportive
interaction—Taking these supplements may support or otherwise help your medication
work better. |
DHEA* |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Reduced drug absorption/bioavailability |
None known |
| Adverse interaction |
None known |
Interactions with Dietary Supplements
DHEA
DHEA supplementation (50 mg per day) has been shown to restore the response of beta-endorphin
(a brain chemical involved in pain and pleasure sensations) to clonidine.1
Interactions with Foods and Other Compounds
Alcohol
Alcohol is a central nervous system depressant and can cause drowsiness and dizziness.
Clonidine may intensify these effects, increasing the risk of accidental injury.2
To avoid problems, people taking clonidine should avoid alcohol.
References:
1. Stomati M, Rubino S, Spinetti A, et al. Endocrine, neuroendocrine and behavioral effects of oral dehydroepiandrosterone sulfate supplementation in postmenopausal women. Gynecol Endocrinol 1999;13:15–25.
2. Threlkeld DS, ed. Central Nervous System Drugs, Central Analgesics, Clonidine HCl. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1997, 246g–6k.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Learn more about Healthnotes, the company.
Learn more about the authors of Safetychecker.
The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.
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