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Safetychecker Summary for Albuterol (for details about the summarized interactions, read the full article) May be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them. Calcium* Magnesium* Potassium* Phosphate* May be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better. Coleus* Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details. Digitalis Side effect reduction/prevention None known Reduced drug absorption/bioavailability None known Adverse interaction None known Interactions with Dietary Supplements Minerals Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.1 Decreased potassium levels have been reported with oral,2 intramuscular, and subcutaneous albuterol administration.3 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown. Interactions with Herbs Digitalis (Digitalis lanata, Digitalis purpurea) Digitalis refers to a family of plants (commonly called foxglove) that contain digitalis glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin. In a small study of salbutamol (albuterol) in people receiving digoxin, albuterol was associated with decreased serum digoxin levels.4 No interactions between albuterol and digitalis have been reported. Until more is known, albuterol and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use. Coleus A test tube study demonstrated that the bronchodilating effects of salbutamol (albuterol) were significantly increased by the addition of forskolin, the active component of the herb Coleus forskohlii. 5 The results of this preliminary research suggest that the combination of forskolin and beta-agonists such as albuterol might provide an alternative to raising the doses of the beta-agonist drugs as they lose effectiveness. Until more is known, coleus should not be combined with albuterol without the supervision of a doctor. Interactions with Foods and Other Compounds Food Albuterol may be taken with food to prevent stomach upset.6 References: 1. Phillips PJ, Vedig AE, Jones PL, et al. Metabolic and cardiovascular side effects of the beta 2-adrenoceptor agonists salbutamol and rimiterol. Br J Clin Pharmacol 1980;9:483–91. 2. Edner M, Jogestrand T. Oral salbutamol decreases serum digoxin concentration. Eur J Clin Pharmacol 1990;38:195–7. 3. Spector SL. Adverse reactions associated with parenteral beta agonists: serum potassium changes. N Engl Reg Allergy Proc 1987;8:317–22. 4. Edner M, Jogestrand T. Oral salbutamol decreases serum digoxin concentration. Eur J Clin Pharmacol 1990;38:195–7. 5. Yousif MH, Thulesius O. Forskolin reverses tachyphylaxis to the bronchodilator effects of salbutamol: an in-vitro study on isolated guinea-pig trachea. J Pharm Pharmacol 1999;51:181–6. 6. Threlkeld DS, ed. Respiratory Drugs, Bronchodilators, Sympathomimetics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1994, 174a–5. Copyright © 2002 Healthnotes, Inc.  All rights reserved. www.healthnotes.com Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. Learn more about Healthnotes, the company. Learn more about the authors of Safetychecker. The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

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