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	Search Quick Order Form» Departments Vitamins Minerals Supplements Herbs Home & Grocery Diet & Fitness Body & Bath More Ways to Shop Brands A-Z Natural Remedies Children & Infants Women's Health Men's Health Seniors Free Catalog MotherNature.com's Catalog Is Here! Click Here to Get Your Free Copy Today. Newsletter Sign Up Weekly health news, sale announcements and coupons!		Library Home > Safetychecker by Drug Name > Fenofibrate FENOFIBRATE Introduction Safetychecker summary Vitamin interactions Food interactions References Visit The Healthy Living Bookshelf: 21 Online Health Books From Rodale Fenofibrate is used to lower elevated cholesterol and triglyceride levels when diet, exercise, and weight loss programs are ineffective. It is in a family of medications known as cholesterol-lowering drugs. Safetychecker Summary for Fenofibrate (for details about the summarized interactions, read the full article) May be Beneficial: Side effect reduction/prevention—Taking these supplements may help reduce the likelihood and/or severity of a potential side effect caused by the medication. Folic acid Vitamin B12 Vitamin B6 Vitamin C Vitamin E May be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better. Food Depletion or interference None known Reduced drug absorption/bioavailability None known Adverse interaction None known Interactions with Dietary Supplements Vitamin C and Vitamin E Several studies have shown that fenofibrate enhances the toxic effect of ultraviolet (UV) radiation from the sun, which might result in side effects such as skin rashes. One controlled study showed that taking 2 grams of vitamin C and 1,000 IU of vitamin E prior to ultraviolet exposure dramatically blocked UV-fenofibrate damage to red blood cells.1 though further controlled studies are needed, people taking fenofibrate should probably supplement with vitamins C and E until more information is available. Folic acid, Vitamin B6, and Vitamin B12 Increased blood levels of homocysteine are associated with increased risk of atherosclerosis and heart disease. One study revealed that fenofibrate dramatically increases blood homocysteine levels, though blood levels of vitamins were not reduced.2 Further research is needed to determine whether supplemental folic acid, vitamin B6, and vitamin B12 might lower fenofibrate-induced elevations in homocysteine blood levels. Interactions with Foods and Other Compounds Food Taking fenofibrate together with food dramatically increases the absorption of the drug.3 Therefore fenofibrate should be taken with a meal. References: 1. Eberlein-Konig B, Placzek M, Przybilla B. Phototoxic lysis of erythrocytes from humans is reduced after oral intake of ascorbic acid and d-alpha-tocopherol. Photodermatol Photoimmunol Photomed 1997;13:173–7. 2. Dierkes J, Westphal S, Luley C. Serum homocysteine increases after therapy with fenofibrate or bezafibrate. Lancet 1999;354:219–20. 3. Sifton DW, et. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 476–8. Copyright © 2002 Healthnotes, Inc.  All rights reserved. www.healthnotes.com Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. Learn more about Healthnotes, the company. Learn more about the authors of Safetychecker. The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

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