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OLANZAPINE

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Olanzapine is used to treat the symptoms associated with psychotic disorders, especially schizophrenia.

Safetychecker Summary for Olanzapine
(for details about the summarized interactions, read the full article)

Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.

Alcohol

Smoking

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

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Interactions with Foods and Other Compounds

Smoking
Cigarette smoking increases the elimination of olanzapine from the body.1 This interaction becomes a problem when an individual who has been taking olanzapine voluntarily starts or quits smoking. People who start smoking while taking olanzapine may experience increased disease symptoms, while those who stop smoking while taking the drug may experience increased side effects. Individuals who change their smoking habits while on olanzapine should notify their doctor.

Alcohol
Ingestion of alcohol may decrease blood levels of olanzapine by stimulating the liver to break down the drug.2 Consequently, individuals who begin using alcohol while taking olanzapine may experience increased disease symptoms due to the reduced effectiveness of the drug. In addition, people who take antipsychotic agents such as olanzapine should avoid alcohol because it may intensify the effects of the drug on the nervous system and may cause low blood pressure.3

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References: Top

1. Ereshefsky L. Pharmacologic and pharmacokinetic considerations in choosing an antipsychotic. J Clin Psychiatry 1999;60(Suppl 10):20–30.

2. Ereshefsky L. Pharmacologic and pharmacokinetic considerations in choosing an antipsychotic. J Clin Psychiatry 1999;60(Suppl 10):20–30.

3. Threlkeld DS, ed. Central Nervous System Drugs, Antipsychotic Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparison, 1999, 1693.

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