Current customer? Log In

	Search Quick Order Form» Departments Vitamins Minerals Supplements Herbs Home & Grocery Diet & Fitness Body & Bath More Ways to Shop Brands A-Z Natural Remedies Children & Infants Women's Health Men's Health Seniors Newsletter Sign Up Weekly health news, sale announcements and coupons!		Library Home > Safetychecker by Drug Name > Clorazepate Dipotassium CLORAZEPATE DIPOTASSIUM Introduction Safetychecker summary Vitamin interactions Food interactions References Clorazepate is used to treat the symptoms of anxiety, including restlessness, insomnia, and worry; it is also used for convulsions and symptoms associated with acute alcohol withdrawal. It is in a class of drugs known as benzodiazepines. Safetychecker Summary for Clorazepate Dipotassium (for details about the summarized interactions, read the full article) May be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better. Vinpocetine* Avoid: Reduced drug absorption/bioavailability—Avoid these supplements when taking this medication since the supplement may decrease the absorption and/or activity of the medication in the body. Tobacco Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. Alcohol Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details. L-tryptophan* Depletion or interference None known Side effect reduction/prevention None known Interactions with Dietary Supplements L-tryptophan Test tube studies show that L-tryptophan and clorazepate dipotassium interact in the blood in such a way that the actions of the drug may be enhanced when high amounts of L-tryptophan are ingested.1 Controlled research is needed to determine the significance of this interaction and to investigate possible interactions between clorazepate and 5-hydroxytryptophan, a supplement related to L-tryptophan. Vinpocetine In a preliminary trial, an extract of periwinkle called vinpocetine was shown to produce minor improvements in short-term memory among people taking flunitrazepam, a benzodiazepine.2 Further study is needed to determine if vinpocetine would be a helpful adjunct to use of benzodiazepines, or clorazepate specifically. Interactions with Foods and Other Compounds Alcohol Drinking alcohol while taking clorazepate may enhance drowsiness and slow reaction time,3 and, according to animal studies, prolong sleep time.4 Consequently, people taking clorazepate dipotassium should avoid alcoholic beverages. Smoking Cigarette smoking decreases the amount of time clorazepate is in the body, lowers blood levels of the drug, and reduces the beneficial effects;5 therefore, people should avoid smoking while taking the drug. People who quit smoking while taking clorazepate might experience unwanted side effects due to increased blood levels of the drug; gradual reduction in nicotine is preferred. References: 1. Coassolo P, Briand C, Bourdeaux M, Sari JC. Microcalorimetric method to determine competitive binding. Action of a psychotropic drug (dipotassium clorazepate) on L-tryptophan human serum albumin complex. Biochem Biophys Acta 1978;538:512–20. 2. Bhatti JZ, Hindmarch I. Vinpocetine effects on cognitive impairments produced by flunitrazepam. Int Clin Psychopharmacol 1987;2:325–31. 3. Threlkeld DS, ed. Central Nervous System Drugs, Psychotherapeutic Drugs, Antianxiety Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 1993, 1255–69. 4. Sifton, DW, ed. Physicians Desk Reference. Montvale, NJ; Medical Economics Company, Inc., 2000, 475–6. 5. Norman TR, Fulton A, Burrows GD, Maguire KP. Pharmacokinetics of N-desmethyldiazepam after a single oral dose of clorazepate: the effect of smoking. Eur J Clin Pharmacol 1981;21:229–33. Copyright © 2002 Healthnotes, Inc.  All rights reserved. www.healthnotes.com Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. Learn more about Healthnotes, the company. Learn more about the authors of Safetychecker. The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

New! 24x7 Ordering by Phone. Call 1-800-439-5506

Information on this site is provided for informational purposes and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. Information about each product is taken from the labels of the products or from the manufacturer's advertising material. MotherNature.com is not responsible for any statements or claims that various manufacturers make about their products. We cannot be held responsible for typographical errors or product formulation changes. You should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.All discounts are taken from suggested retail prices.

Please see our Terms of Use
Copyright © 1995-2009 Mother Nature, Inc. All rights reserved.