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	Search Quick Order Form» Departments Vitamins Minerals Supplements Herbs Home & Grocery Diet & Fitness Body & Bath More Ways to Shop Brands A-Z Natural Remedies Children & Infants Women's Health Men's Health Seniors Newsletter Sign Up Weekly health news, sale announcements and coupons!		Library Home > Safetychecker by Drug Name > Cisapride CISAPRIDE Introduction Safetychecker summary Herb interactions Food interactions References Cisapride is a gastrointestinal stimulant drug used to treat people with nighttime heartburn due to reflux of stomach acid into the esophagus. It is also used to increase movement of gastrointestinal contents in conditions of lack of spontaneous gastrointestinal movement. Safetychecker Summary for Cisapride (for details about the summarized interactions, read the full article) May be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them. Menthol-containing herbs such as peppermint Avoid: Reduced drug absorption/bioavailability—Avoid these supplements when taking this medication since the supplement may decrease the absorption and/or activity of the medication in the body. Tobacco Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. Grapefruit juice Red wine Side effect reduction/prevention None known Supportive interaction None known Interactions with Herbs Menthol-containing herbs People with esophageal reflux should avoid use of menthol-containing herbs, such as peppermint; the volatile oils in these plants may decrease the pressure in the lower esophageal sphincter and make the reflux worse.1 Interactions with Foods and Other Compounds Alcohol Alcohol consumption is associated with nighttime heartburn and may interfere with cisapride therapy.2 Alcohol causes sleepiness, and cisapride may intensify this effect,3 increasing the risk of accidental injury. Ingestion of red wine along with cisapride may also increase blood levels of the drug in some individuals, potentially increasing its side effects.4 People taking cisapride should avoid alcohol.. Tobacco Smoking is associated with nighttime heartburn and may interfere with cisapride therapy.5 Smokers taking cisapride may benefit from reducing or quitting smoking. Grapefruit juice In a study of healthy males, ingestion of 250 ml (about one cup) of grapefruit juice along with cisapride increased the peak blood level of the drug by an average of 68%.6 It is not known whether consuming grapefruit juice at a separate time of the day would affect blood levels of cisapride. As this interaction could potentially increase the side effects of cisapride, individuals taking cisapride should avoid grapefruit and its juice.> References: 1. Sigmund CJ, McNally EF. The action of a carminative on the lower esophageal sphincter. Gastroenterol 1969;56:13–8. 2. Threlkeld DS, ed. Gastrointestinal Drugs, GI Stimulants, Cisapride. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Nov 1998, 308b–8c. 3. Threlkeld DS, ed. Gastrointestinal Drugs, GI Stimulants, Cisapride. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Nov 1998, 308b–8c. 4. Offman EM, Freeman DJ, Dresser GK, et al. Red wine-cisapride interaction: comparison with grapefruit juice. Clin Pharmacol Ther 2001;70:17–23. 5. Threlkeld DS, ed. Gastrointestinal Drugs, GI Stimulants, Cisapride. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Nov 1998, 308b–8c. 6. Offman EM, Freeman DJ, Dresser GK, et al. Red wine-cisapride interaction: comparison with grapefruit juice. Clin Pharmacol Ther 2001;70:17–23. Copyright © 2002 Healthnotes, Inc.  All rights reserved. www.healthnotes.com Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. Learn more about Healthnotes, the company. Learn more about the authors of Safetychecker. The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

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