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BACLOFEN

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Baclofen is used to treat muscle spasms associated with multiple sclerosis and spinal cord injury, and it may help with face pain due to trigeminal neuralgia. It is in a class of drugs known as centrally acting skeletal muscle relaxants.

Safetychecker Summary for Baclofen
(for details about the summarized interactions, read the full article)

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

Adverse interaction

None known

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Interactions with Foods and Other Compounds

Food
Baclofen absorption is not affected by food, but the drug should be taken with a meal to minimize stomach upset.1

Alcohol
Drinking alcohol may enhance the side effects of baclofen, such as drowsiness, dizziness, weakness, and fatigue.2 Therefore, people taking baclofen should avoid alcoholic beverages, especially if staying alert is necessary.

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References: Top

1. Peterson GM, McLean S, Millingen KS. Food does not affect the bioavailability of baclofen. Med J Aust 1985;142:689–90.

2. Olin BR, ed. Central Nervous System Drugs, Muscle Relaxants, Centrally Acting. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 1993, 1529–30.

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