ELEUTHERO

Parts used and where grown: Eleuthero belongs to the Araliaceae family and is a distant relative of Asian ginseng (Panax ginseng). Also known commonly as touch-me-not and devil’s shrub, eleuthero has been most frequently nicknamed Siberian ginseng in this country. Eleuthero is native to the Taiga region of the Far East (southeastern part of Russia, northern China, Korea, and Japan). The root and the rhizomes (underground stem) are used medicinally.

Eleuthero has been used in connection with the following conditions (refer to the individual health concern for complete information):

Rating	Health Concerns
	Athletic performance Fatigue Immune function Stress
	Breast cancer Chronic fatigue syndrome Common cold/sore throat Diabetes HIV support Infection Influenza
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.

Historical or traditional use (may or may not be supported by scientific studies): Although not as popular as Asian ginseng, eleuthero use dates back 2,000 years, according to Chinese medicine records. Referred to as ci wu jia in Chinese medicine, it was used to prevent respiratory tract infections, colds and flu. It was also believed to provide energy and vitality. In Russia, eleuthero was originally used by people in the Siberian Taiga region to increase performance and quality of life and to decrease infections.

In more modern times, eleuthero has been used to increase stamina and endurance in Soviet Olympic athletes. Russian explorers, divers, sailors, and miners also used eleuthero to prevent stress-related illness. After the Chernobyl accident, many Russian and Ukrainian citizens were given eleuthero to counteract the effects of radiation.

Active constituents: The constituents in eleuthero that have been most studied are the eleutherosides.¹ Seven primary eleutherosides have been identified, with most of the research attention focusing on eleutherosides B and E.² Eleuthero also contains complex polysaccharides (complex sugar molecules).³ These constituents may play a critical role in eleuthero’s ability to support immune function.

Eleuthero is an “adaptogen” (an agent that helps the body adapt to stress). It is thought to help support adrenal gland function when the body is challenged by stress.⁴

Eleuthero has been shown to enhance mental acuity and physical endurance without the letdown that comes with caffeinated products.⁵ Research has shown that eleuthero improves the use of oxygen by the exercising muscle.⁶ This means that a person is able to maintain aerobic exercise longer and recover from workouts more quickly. Preliminary research from Russia indicates it may be effective for this purpose.⁷ Other trials have been inconclusive⁸ or have shown no beneficial effect.⁹

Eleuthero may also support the body by helping the liver detoxify harmful toxins. It has shown a protective action in animal studies against chemicals such as ethanol, sodium barbital, tetanus toxoid, and chemotherapeutic agents.¹⁰ According to a test tube study eleuthero also helps protect the body during radiation exposure.¹¹ Preliminary research in Russia has suggested that eleuthero may help alleviate side effects and help the bone marrow recover more quickly in people undergoing chemotherapy and radiation therapy for cancer.¹²

Eleuthero may be useful as a preventive measure during the cold and flu season. However, it has not yet been specifically studied for this purpose. Preliminary evidence also suggests that eleuthero may prove valuable in the long-term management of various diseases of the immune system, including HIV infection and chronic fatigue syndrome. Healthy people taking 2 teaspoons (10 ml) of tincture three times daily have been shown to have increased numbers of the immune cells (T4 lymphocytes) that have been found to decrease during HIV-infection and AIDS.¹³ Further human clinical trials are needed to confirm that eleuthero may be helpful for this disease.

How much is usually taken? Dried, powdered root and rhizomes, 2–3 grams per day, are commonly used.¹⁴ Alternatively, 300–400 mg per day of concentrated solid extract standardized on eleutherosides B and E can be used, as can alcohol-based extracts, 8–10 ml in two to three divided dosages. Historically, eleuthero is taken continuously for six to eight weeks, followed by a one- to two-week break before resuming.

Are there any side effects or interactions? Reported side effects have been minimal with use of eleuthero.¹⁵ Mild, transient diarrhea has been reported in a very small number of users. Eleuthero may cause insomnia in some people if taken too close to bedtime. Eleuthero is not recommended for people with uncontrolled high blood pressure. There are no known reasons to avoid eleuthero during pregnancy and breast-feeding. However, pregnant or breast-feeding women should be aware that some products may be adulterated with herbs that should not be taken in pregnancy, such as Asian ginseng. Only eleuthero from a trusted source should be used.

In one case report, a person taking eleuthero with digoxin developed dangerously high serum digoxin levels.¹⁶ Although a clear relationship could not be established, it is wise for someone taking digoxin to seek the advise of a doctor before taking eleuthero.

Are there any drug interactions? Certain medications may interact with eleuthero. Refer to the drug interactions safety check for a list of those medications.

1. Collisson RJ. Siberian ginseng (Eleutherococcus senticosus). Brit J Phytother 1991;2:61–71 [review].

2. Farnsworth NR, Kinghorn AD, Soejarto DD, Waller DP. Siberian ginseng (Eleutherococcus senticosus): Current status as an adaptogen. In Economic and Medicinal Plant Research, vol 1, ed. Wagner H, Hikino HZ, Farnsworth NR. London: Academic Press, 1985, 155–215 [review].

3. Hikino H, Takahashi M, Otake K, konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F and G: glycans of Eleutherococcus senticosus roots. J Natural Prod 1986;49:293–7.

4. Wagner H, Nörr H, Winterhoff H. Plant adaptogens. Phytomed 1994;1:63–76 [review].

5. Farnsworth NR, Kinghorn AD, Soejarto DD, Waller DP. Siberian ginseng (Eleutherococcus senticosus): Current status as an adaptogen. In Economic and Medicinal Plant Research, vol 1, ed. Wagner H, Hikino HZ, Farnsworth NR. London: Academic Press, 1985, 155–215 [review].

6. Asano K, Takahashi T, Miyashita M, et al. Effect of Eleutherococcus senticosus extract on human working capacity. Planta Medica 1986;37:175–7.

7. Asano K, Takahashi T, Miyashita M, et al. Effect of Eleutherococcus senticosus extract on human working capacity. Planta Medica 1986;37:175–7.

8. Kelly GS. Sports nutrition: A review of selected nutritional supplements for endurance athletes. Alt Med Rev 1997;2:282–95 [review].

9. McNaughton L. A comparison of Chinese and Russian ginseng as ergogenic aids to improve various facets of physical fitness. Int Clin Nutr Rev 1989;9:32–5.

10. Collisson RJ. Siberian ginseng (Eleutherococcus senticosus). Brit J Phytother 1991;2:61–71 [review].

11. Ben-Hur E, Fulder S. Effect of P. ginseng saponins and Eleutherococcus S. on survival of cultured mammalian cells after ionizing radiation. Am J Chin Med 1981;9:48–56.

12. Kupin VI, Polevaia EB. Stimulation of the immunological reactivity of cancer patients by eleutherococcus extract. Vopr Onkol 1986;32:21–6 [in Russian].

13. Bohn B, Nebe CT, Birr C. Flow cytometric studies with Eleutherococcus senticosus extract as an immunomodulating agent. Arzneim-Forsch Drug Res 1987;37:1193–6.

14. Brown DJ. Herbal Prescriptions for Better Health. Rocklin, CA: Prima Publishing, 1996, 69–77.

15. McGuffin M, Hobbs C, Upton R, Goldberg A. American Herbal Products Association’s Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 45.

16. McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. Can Med Assoc J 1996;155:293–5.

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