BUGLEWEED

Parts used and where grown: The leaves and flowers of this plant from the mint family are used medicinally. Both bugleweed and its European cousin, gypsywort (Lycopus europaeus), grow in very wet areas.

Bugleweed has been used in connection with the following conditions (refer to the individual health concern for complete information):

Rating	Health Concerns
	Breast pain Hyperthyroidism
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.

Historical or traditional use (may or may not be supported by scientific studies): The modern applications of bugleweed, unlike many medicinal plants, do not match its traditional use. Historically, bugleweed and related species were used to treat coughs and as a sedative.¹ Today, the main use of this herb is for treating mild hyperthyroidism.

Active constituents: Lithospermic acid and other organic acids are believed to be responsible for bugleweed’s activity. These acids decrease levels of several hormones in the body, particularly thyroid-stimulating hormones² and the thyroid hormone thyroxine (T4).³ Bugleweed inhibits the binding of antibodies to the thyroid gland.⁴ These antibodies can cause the most common form of hyperthyroidism, Graves’ disease. All these actions may help explain bugleweed’s benefit in people with mildly overactive thyroids.

How much is usually taken? The German Commission E monograph recommends 1–2 grams of the whole herb per day.⁵ Intake of tincture should be limited to 1–2 ml three times a day. Bugleweed is often combined with other herbs used to treat mildly overactive thyroid function, including lemon balm (Melissa officinalis) and gromwell (Lithospermum ruderale).

Are there any side effects or interactions? Excessive intake of bugleweed by people with thyroid disease or use by healthy people may cause a potentially harmful decrease in thyroid function. Thyroid disease is dangerous and should only be treated under the supervision of a healthcare professional. However, long-term use of bugleweed is considered safe for people with hyperthyroidism.⁶ Bugleweed should not be taken by people with hypothyroidism. Bugleweed should also not be used during pregnancy and breast-feeding.⁷

Are there any drug interactions? Certain medications may interact with bugleweed. Refer to the drug interactions safety check for a list of those medications.

1. Wren RC, Williamson EM, Evans FJ. Potter’s New Cyclopaedia of Botanical Drugs and Preparations. Essex, UK: Saffron Walden, 1988, 47–8.

2. Wagner H, Horhammer L, Frank U. Lithospermic acid, the antihormonally active principle of Lycopus europaeus L. and Symphytum officinale L. Arzneim Forsch 1970;20:705–12.

3. Winterhoff H, Gumbinger HG, Vahlensieck U, et al. Ednocrine effects of Lycopus europaeus L. following oral application. Arzneimittlforschung 1994;44:41–5.

4. Auf’mkolk M, Ingbar JC, Kubota K, et al. Extracts and auto-oxidized constituents of certain plants inhibit the receptor-binding and biological activity of Graves’ immunoglobulins. Endocrin 1985;116:1687–93.

5. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 98–9.

6. Weiss RF. Herbal Medicine. Beaconsfield, UK: Beaconsfield Publishers Ltd., 1988, 328–9.

7. Brinker F. Inhibition of endocrine function by botanical agents. I. Boraginaceae and Labiatae. J Naturopathic Med 1990;1:10–8.

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