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	Search Quick Order Form» Departments Vitamins Minerals Supplements Herbs Home & Grocery Diet & Fitness Body & Bath More Ways to Shop Brands A-Z Natural Remedies Children & Infants Women's Health Men's Health Seniors Free Catalog MotherNature.com's Catalog Is Here! Click Here to Get Your Free Copy Today. Newsletter Sign Up Weekly health news, sale announcements and coupons!		Library Home > Safetychecker by Drug Name > Trazodone TRAZODONE Introduction Safetychecker summary Herb interactions Food interactions References Visit The Healthy Living Bookshelf: 21 Online Health Books From Rodale Trazodone is a weak serotonin reuptake inhibitor drug with other effects on brain neurotransmitters. It is used to treat people with depression. It is also used to treat people during cocaine withdrawal. Safetychecker Summary for Trazodone (for details about the summarized interactions, read the full article) Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. Ginkgo biloba * St. John’s wort* Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details. Digitalis Depletion or interference None known Side effect reduction/prevention None known Supportive interaction None known Reduced drug absorption/bioavailability None known Interactions with Herbs Digitalis (Digitalis lanata, Digitalis purpurea) Digitalis refers to a family of plants commonly called foxglove that contain digitalis glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin. Trazodone was associated with increased serum digoxin levels in one case report.1 No interactions between trazodone and digitalis have been reported. Until more is known, trazodone and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use. Ginkgo biloba There is one case report of an elderly patient with Alzheimer’s disease going into a coma while concurrently using trazodone and ginkgo.2 Until more is known, ginkgo should not be combined with trazodone except under supervision of a doctor. St. John’s wort (Hypericum perforatum) One report described a case of serotonin syndrome in a patient who took St. John’s wort and trazodone.3 The patient reportedly experienced mental confusion, muscle twitching, sweating, flushing, and ataxia. Until more is known, St. John’s wort should not be combined with trazodone except under expert clinical supervision. Interactions with Foods and Other Compounds Food Trazodone should be taken with food.4 Alcohol Trazodone may cause drowsiness or dizziness.5 Alcohol may compound these effects and increase the risk of accidental injury. To prevent problems, people taking trazodone should avoid alcohol. References: 1. Rauch PK, Jenike MA. Digoxin toxicity possibly precipitated by trazodone. Psychosomatics 1984;25:334–5. 2. Galluzzi S, Zanetti O, Binetti G, et al. Coma in a patient with Alzheimer’s disease taking low dose trazodone and Ginkgo biloba. J Neurol Neurosurg Psychiatry 2000;68:679–80. 3. Demott K. St. John’s wort tied to serotonin syndrome. Clinical Psychiatry News 1998;26:28. 4. Threlkeld DS, ed. Central Nervous System Drugs, Antidepressants, Trazodone. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Apr 1990, 263i–3k. 5. Threlkeld DS, ed. Central Nervous System Drugs, Antidepressants, Trazodone. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Apr 1990, 263i–3k. Copyright © 2002 Healthnotes, Inc.  All rights reserved. www.healthnotes.com Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. Learn more about Healthnotes, the company. Learn more about the authors of Safetychecker. The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

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