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	Search Quick Order Form» Departments Vitamins Minerals Supplements Herbs Home & Grocery Diet & Fitness Body & Bath More Ways to Shop Brands A-Z Natural Remedies Children & Infants Women's Health Men's Health Seniors Free Catalog MotherNature.com's Catalog Is Here! Click Here to Get Your Free Copy Today. Newsletter Sign Up Weekly health news, sale announcements and coupons!		Library Home > Safetychecker by Drug Name > Sildenafil SILDENAFIL Introduction Safetychecker summary References Visit The Healthy Living Bookshelf: 21 Online Health Books From Rodale Sildenafil is a drug used to treat erectile dysfunction (ED), commonly known as impotence, in men. In one study, ingestion of 250 ml (approximately one cup) of grapefruit juice one hour before and together with sildenafil increased the total amount of sildenafil absorbed by 23%, but tended to delay the absorption of the drug.1 The authors of this study recommended that sildenafil and grapefruit juice not be taken together. Safetychecker Summary for Sildenafil (for details about the summarized interactions, read the full article) Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. Grapefruit juice Depletion or interference None known Side effect reduction/prevention None known Supportive interaction None known Reduced drug absorption/bioavailability None known References: 1. Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, et al. Effects of grapefruit juice on the pharmacokinetics of sildenafil. Clin Pharmacol Ther 2002;71:21–9. Copyright © 2002 Healthnotes, Inc.  All rights reserved. www.healthnotes.com Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. Learn more about Healthnotes, the company. Learn more about the authors of Safetychecker. The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

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