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	Search Quick Order Form» Departments Vitamins Minerals Supplements Herbs Home & Grocery Diet & Fitness Body & Bath More Ways to Shop Brands A-Z Natural Remedies Children & Infants Women's Health Men's Health Seniors Free Catalog MotherNature.com's Catalog Is Here! Click Here to Get Your Free Copy Today. Newsletter Sign Up Weekly health news, sale announcements and coupons!		Library Home > Safetychecker by Drug Name > Sibutramine SIBUTRAMINE Introduction Safetychecker summary Vitamin interactions Herb interactions Food interactions References Visit The Healthy Living Bookshelf: 21 Online Health Books From Rodale Sibutramine is used for the management of obesity, including weight loss and maintenance of weight loss, and should be used in association with a reduced calorie diet. Safetychecker Summary for Sibutramine (for details about the summarized interactions, read the full article) Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. 5-HTP Alcohol Ephedra L-tryptophan Depletion or interference None known Side effect reduction/prevention None known Supportive interaction None known Reduced drug absorption/bioavailability None known Interaction with Dietary Supplements L-Tryptophan and 5-HTP The amino acids L-tryptophan and 5-hydroxytryptophan (5-HTP) are occasionally used to treat mental depression. Taking sibutramine with L-tryptophan or 5-HTP might result in a rare, but serious group of symptoms known as “serotonin syndrome.”1 Symptoms associated with serotonin syndrome may include confusion, anxiety, muscle weakness, incoordination, and vomiting. Therefore, individuals taking sibutramine should avoid supplementing with L-tryptophan and 5-HTP. Interaction with Herbs Ephedra  (Ephedra sinica) One side effect of sibutramine is high blood pressure. Ephedra, an herb used in cold remedies and herbal weight loss products, contains ephedrine, which can also increase blood pressure. Though no studies have investigated whether taking sibutramine together with ephedra might produce an adverse interaction, currently available evidence suggests that this combination should be used with caution.2 Interaction with Food and Other Compounds Alcohol Though one controlled study showed that drinking alcoholic beverages while taking sibutramine produced no clinically important interaction, it is nevertheless recommended that individuals taking the drug should avoid drinking alcohol.3 References: 1. Sifton DW, et. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc. 2000, 1509–13. 2. Sifton DW, et. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc. 2000, 1509–13. 3. Sifton DW, et. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc. 2000, 1509–13. Copyright © 2002 Healthnotes, Inc.  All rights reserved. www.healthnotes.com Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. Learn more about Healthnotes, the company. Learn more about the authors of Safetychecker. The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

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