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PROMETHAZINE

Promethazine is an antihistamine used to relieve allergic rhinitis (seasonal allergy) symptoms including sneezing, runny nose, itching, and watery eyes and itching and swelling associated with uncomplicated allergic skin reactions. It is also used as a sleep aid for surgical procedures and to prevent/treat motion sickness, nausea, and vomiting. Promethazine is available as a nonprescription product alone and in a combination product to treat symptoms of allergy, colds, and upper respiratory infections. It is also available in prescription products with codeine, to treat coughs associated with colds and upper respiratory infections.

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Safetychecker Summary for Promethazine
(for details about the summarized interactions, read the full article)

Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.

Henbane*

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

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Interactions with Herbs

Henbane (Hyoscyamus niger)
Antihistamines, including promethazine, can cause “anticholinergic” side effects such as dryness of mouth and heart palpitations. Henbane also has anticholinergic activity and side effects. Therefore, use with promethazine could increase the risk of anticholinergic side effects,1 though apparently no interactions have yet been reported with promethazine and henbane. Henbane should not be taken except by prescription from a physician trained in its use, as it is extremely toxic.

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Interactions with Foods and Other Compounds

Alcohol
Promethazine causes drowsiness.2 Alcohol may intensify this effect and increase the risk of accidental injury.3 To prevent problems, people taking promethazine or promethazine-containing products should avoid alcohol.

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References: Top

1. Blumenthal M, ed. The Complete German Commission E Monographs. Austin, TX: American Botanical Council, 1998, 146.

2. Threlkeld DS, ed. Respiratory Drugs, Antihistamines. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1998, 192b–2c.

3. Threlkeld DS, ed. Respiratory Drugs, Antihistamines. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1998, 192b–2c.

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