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DILTIAZEM

Visit The Healthy Living Bookshelf:

Safetychecker Summary for Diltiazem
(for details about the summarized interactions, read the full article)

Avoid Avoid: Reduced drug absorption/bioavailability—Avoid these supplements when taking this medication since the supplement may decrease the absorption and/or activity of the medication in the body.

DHEA

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Adverse interaction

None known

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Interactions with Dietary Supplements

Dehydroepiandrosterone (DHEA)
Diltiazem has been shown to raise blood levels of DHEA and DHEA-sulfate in insulin-resistant, obese men with high blood pressure.1

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Interactions with Herbs

Pleurisy root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as calcium channel blockers.2

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Interactions with Foods and Other Compounds

Food
Diltiazem may be taken with or without food.3 Sustained-release diltiazem products should be swallowed whole, without opening, crushing, or chewing.4

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References: Top

1. Beer NA, Jakubowicz DJ, Beer RM, Nestler JE. Disparate effects of insulin reduction with diltiazem on serum dehydroepiandrosterone sulfate levels in obese hypertensive men and women. J Clin Endocrinol Metab 1994;79:1077–81.

2. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.

3. Du Souich P, Lery N, Lery L, et al. Influence of food on the bioavailability of diltiazem and two of its metabolites following the administration of conventional tablets and slow-release capsules. Biopharm Drug Dispos 1990;11:137–47.

4. Threlkeld DS, ed. Diuretics and Cardiovasculars, Calcium Channel Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1996, 149r–9t.

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