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Library Home > Safetychecker by Drug Name > Bile Acid Sequestrants

BILE ACID SEQUESTRANTS

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Cholestyramine (Questran®) and colestipol (Colestid®) are bile acid sequestrants—a class of drugs that binds bile acids, prevents their reabsorption from the digestive system, and reduces cholesterol levels. Cholestyramine and colestipol are two of many drugs used to lower cholesterol levels in people with high cholesterol.

Bile acids are produced in the liver from cholesterol and secreted into the small intestine to help with the absorption of dietary fat and cholesterol. Bile acid sequestrants bind bile acids in the small intestine and carry them out of the body. This causes the body to use more cholesterol to make more bile acids, which are secreted into the small intestine, bound to bile acid sequestrants, and carried out of the body. The end result is lower cholesterol levels. Bile acid sequestrants also prevent absorption of some dietary cholesterol.

The information in this article pertains to bile acid sequestrants in general. The interactions reported here may not apply to all the Also Indexed As terms. Talk to your doctor or pharmacist if you are taking any of these drugs.

Safetychecker Summary for Bile Acid Sequestrants
(for details about the summarized interactions, read the full article)

May be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them.	Beta-carotene and other carotenoids Calcium* Folic acid Vitamin A Vitamin D Vitamin E Vitamin K Zinc*
Side effect reduction/prevention	None known
Supportive interaction	None known
Reduced drug absorption/bioavailability	None known
Adverse interaction	None known

Interactions with Dietary Supplements

Vitamins and Minerals
Bile acid sequestrants may prevent absorption of folic acid and the fat-soluble vitamins A, D, E, and K.¹ ² Other medications and vitamin supplements should be taken one hour before or four to six hours after bile acid sequestrants for optimal absorption.³ Animal studies suggest calcium and zinc may also be depleted by taking cholestyramine.⁴

Carotenoids
Use of colestipol for six months has been shown to significantly lower blood levels of carotenoids including beta-carotene.⁵

Interactions with Foods and Other Compounds

Food
Bile acid sequestrants should be taken with plenty of water before meals.⁶

References:

1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 221–2 [review].

2. Threlkeld DS, ed. Diuretics and Cardiovasculars, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1997, 171i–l.

3. Threlkeld DS, ed. Diuretics and Cardiovasculars, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1997, 171i–l.

4. Watkins DW, Cassidy MM, Khalafi R, Vahouny GV. Calcium and zinc balances in rats chronically fed the bile salt-sequestrant cholestyramine (Questran). Fed Proc 1983;42:819.

5. Probstfield JL, Lin T, Peters J, Hunninghake DB. Carotenoids and vitamin A: The effect of hypocholesterolemic agents on serum levels. Metabolism 1985;34:88–91.

6. Threlkeld DS, ed. Diuretics and Cardiovasculars, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1997, 171i–l.

Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.

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Learn more about the authors of Safetychecker.

The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

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