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	Search Quick Order Form» Departments Vitamins Minerals Supplements Herbs Home & Grocery Diet & Fitness Body & Bath More Ways to Shop Brands A-Z Natural Remedies Children & Infants Women's Health Men's Health Seniors Newsletter Sign Up Weekly health news, sale announcements and coupons!		Library Home > Safetychecker by Drug Name > Benzodiazepines BENZODIAZEPINES Introduction Safetychecker summary Vitamin interactions Herb interactions Food interactions References Benzodiazepines are a family of drugs used to treat insomnia, anxiety, panic attacks, muscle spasms, and seizure disorders. One benzodiazepine, midazolam, is used as a general anesthetic. Interactions involving benzodiazepines in general are described on this page. For interactions involving a specific benzodiazepine, refer to the highlighted drugs listed below. Alprazolam (Xanax®) Chlordiazepoxide (Librium®, Libritabs®) Clonazepam (Klonopin®) Clorazepate Dipotassium (Tranxene®) Diazepam (Valium®) Estazolam (ProSom®) Flunitrazepam (Rohypnol®) Flurazepam (Dalmane®) Lorazepam (Ativan®) Midazolam (Versed®) Oxazepam (Serax®) Quazepam (Doral®) Temazepam (Restoril®) Triazolam (Halcion®) Safetychecker Summary for Benzodiazepines (for details about the summarized interactions, read the full article) May be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better. Vinpocetine Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. Alcohol Depletion or interference None known Side effect reduction/prevention None known Reduced drug absorption/bioavailability None known Interactions common to many, if not all, Benzodiazepines are described in this article. Interactions reported for only one or several drugs in this class may not be listed in this article. Some drugs listed in this article are linked to articles specific to that respective drug; please refer to those individual drug articles. The information in this article may not necessarily apply to drugs in this class for which no separate article exists. If you are taking a Benzodiazepine for which no separate article exists, talk with your doctor or pharmacist. Interactions with Dietary Supplements — Vinpocetine In a preliminary trial, an extract of periwinkle called vinpocetine was shown to produce minor improvements in short-term memory among people taking flunitrazepam, a benzodiazepine.1 Further study is needed to determine if vinpocetine would be a helpful adjunct to use of benzodiazepines. Interactions with Herbs — Kava (Piper methysticum) Kava is an herb used to treat anxiety disorder. One individual who took a benzodiazepine (alprazolam) and kava together, along with two other medications (cimetidine and terazosin) was hospitalized in a lethargic and disoriented condition.2 Further research is needed to determine whether the combination of kava and benzodiazepines produces an adverse interaction. However, individuals should not take benzodiazepines and kava together unless supervised by a doctor. Interactions with Foods and Other Compounds Alcohol Drinking alcoholic beverages while taking benzodiazepines may increase side effects, such as drowsiness, confusion, and dizziness;3 if taken in excess, this combination may result in death. Consequently, people taking benzodiazepines should avoid drinking alcohol. References: 1. Bhatti JZ, Hindmarch I. Vinpocetine effects on cognitive impairments produced by flunitrazepam. Int Clin Psychopharmacol 1987;2:325–31. 2. Almeida JC. Coma from the health food store: Interaction between kava and alprazolam. Ann Intern Med 1996;125:940–1. 3. Olin BR, ed. Central Nervous System Drugs, Psychotherapeutic Drugs, Antianxiety Agents, In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 1993, 1255–69. Copyright © 2002 Healthnotes, Inc.  All rights reserved. www.healthnotes.com Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. Learn more about Healthnotes, the company. Learn more about the authors of Safetychecker. The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

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