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	Search Quick Order Form» Departments Vitamins Minerals Supplements Herbs Home & Grocery Diet & Fitness Body & Bath More Ways to Shop Brands A-Z Natural Remedies Children & Infants Women's Health Men's Health Seniors Free Catalog MotherNature.com's Catalog Is Here! Click Here to Get Your Free Copy Today. Newsletter Sign Up Weekly health news, sale announcements and coupons!		Library Home > Safetychecker by Drug Name > Acebutolol ACEBUTOLOL Introduction Safetychecker summary Vitamin interactions Herb interactions Food interactions References Visit The Healthy Living Bookshelf: 21 Online Health Books From Rodale Combination drug: Secradex® Acebutolol is used to treat high blood pressure and certain forms of heart arrhythmia, and is in a family of drugs known as beta-adrenergic blockers. Safetychecker Summary for Acebutolol (for details about the summarized interactions, read the full article) Avoid: Reduced drug absorption/bioavailability—Avoid these supplements when taking this medication since the supplement may decrease the absorption and/or activity of the medication in the body. Food Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. Potassium supplements* Pleurisy root* High-potassium foods* Depletion or interference None known Side effect reduction/prevention None known Supportive interaction None known Interactions with Dietary Supplements Potassium Some beta-adrenergic blockers (called “nonselective” beta blockers) decrease the uptake of potassium from the blood into the cells,1 leading to excess potassium in the blood, a potentially dangerous condition known as hyperkalemia.2 People taking beta-blockers should therefore avoid taking potassium supplements, or eating large quantities of fruit (e.g., bananas), unless directed to do so by their doctor. Interactions with Herbs Pleurisy root As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as beta-blockers.3 Interaction with Foods and Other Compounds Taking acebutolol with food slows the rate of absorption and reduces the maximum blood levels of the drug, though overall absorption is not affected.4 However, the blood level of an active breakdown product of acebutolol is reduced.5 Though the activity of acebutolol is affected by food, people taking the drug on a daily basis are not likely to experience a reduction in the effectiveness of the drug if it is taken with a meal. References: 1. Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med 1980;302:431–4. 2. Lundborg P. The effect of adrenergic blockade on potassium concentrations in different conditions. Acta Med Scand Suppl 1983;672:121–6 [review]. 3. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4. 4. Sifton DW, ed. Physicians Desk Reference. Montvale. NJ: Medical Economics Company, Inc., 2000, 3317–9. 5. Zaman R, Wilkins MR, Kendall MJ, Jack DB. The effect of food and alcohol on the pharmacokinetics of acebutolol and its metabolite, diacetolol. Biopharm Drug Dispos 1984;5:91–5. Copyright © 2002 Healthnotes, Inc.  All rights reserved. www.healthnotes.com Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. Learn more about Healthnotes, the company. Learn more about the authors of Safetychecker. The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.

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